The Path to Resolution: A Stepwise Approach to Pan-Reactive Samples – BIORAD webinars

One of the most significant challenges in the field of immunohematology is encountered when dealing with samples where the plasma reacts with all tested screening and antibody identification red blood cells. This phenomenon can result from various factors, such as autoantibodies, a combination of alloantibodies, an alloantibody against a high-prevalence antigen, or the patient’s ongoing treatment with monoclonal antibodies.

Nevertheless, there is a methodical approach that can be employed to systematically address these samples, leading to a successful resolution and the identification of the underlying causes of pan-reactivity. It is essential to begin with comprehensive information prior to initiating the investigation, and to apply appropriate techniques and tools for the task at hand.

Dr. Jill R. Storry, PhD, will provide insights into the best strategies for approaching these complex cases in your laboratory, ensuring optimal patient care. Dr. Jill Storry serves as an Associate Professor in the Division of Hematology and Transfusion Medicine at Lund University (LU), Sweden. She is responsible for overseeing the immunohematology laboratories within the Department of Clinical Immunology and Transfusion Medicine, Laboratory Medicine, Lund.