Red Blood Cell Genotyping for Improved Medical Care - Meghan Delaney
Embracing the Era of Personalized Medicine: Enhancing Transfusion Outcomes through Molecular Blood Group Typing”
In the context of advancing medical frontiers towards personalized medicine, the utilization of genetic testing is witnessing remarkable growth. This trend extends to the domain of blood transfusion, where an increasing number of laboratories are adopting commercially available molecular red cell testing platforms or enlisting specialized laboratories for certain tests. In this enlightening discourse, we delve into the realm of molecular blood group typing, as presented by Dr. Meghan Delaney. Holding the esteemed positions of Assistant Professor in the Department of Laboratory Medicine at the University of Washington, Medical Director at the Puget Sound Blood Center, and Medical Director of the Blood Bank at Seattle Children’s Hospital, Dr. Delaney elucidates how molecular blood group typing stands to revolutionize transfusion outcomes.
Speaker: Dr. Meghan Delaney, DO, MPH
- Assistant Professor, Department of Laboratory Medicine, University of Washington
- Medical Director, Puget Sound Blood Center
- Medical Director, Blood Bank, Seattle Children’s Hospital
- Overview of a board review session discussing blood group genotyping and transfusion medicine cases.
- Case 1: Hemoglobin drop in a postpartum woman; potential mistransfusion causes.
- Case 2: Challenges in sickle cell patient transfusion; hemoglobin response factors.
- Case 3: Finding compatible units for a patient with multiple antibodies.
Importance of Red Cell Genotyping:
- Red cell genotyping’s role in enhancing medical care and transfusion safety.
- Precision and accuracy surpassing traditional serological methods.
Rh Blood Group Complexity:
- Complexity of Rh blood group, genetic structure of RHD and RHCE genes.
- Importance of accurate typing due to closely located genes.
C and E Alleles in Rh Blood Group:
- Significance of C and E alleles, molecular differences, and immunological implications.
Transfusion Safety and Weak D:
- Understanding weak D and partial D antigens, genetic variations, and antibody production.
- Importance of reagent engineering for weak D individuals.
- Challenges in Rh antigen testing, differentiation of weak D and partial D.
- Implications of blood type mismatches due to ethnic diversity.
- Consequences of mismatched blood transfusions; spectrum of outcomes.
- Rh antibodies’ continued relevance in causing complications.
Hybrid Alleles and Future Implications:
- Importance of hybrid alleles in medical care, especially for sickle cell patients.
- Future implications of genomic methods in blood group genotyping.
Collaboration and Conclusion:
- Acknowledgment of collaborators and achievements.
- Appreciation for audience engagement in exploring blood group genotyping and transfusion medicine.