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Monoclonal Antibodies
Monoclonal Antibodies

Monoclonal Antibodies

Monoclonal Antibodies


Monoclonal antibody therapies have revolutionized the field of medicine, offering promising treatment options for various conditions. In this informative video, we delve into the world of monoclonal antibody therapies and their implications in blood banking. Join us as we explore the applications, challenges, and management strategies associated with these groundbreaking therapies.

  1. Understanding Monoclonal Antibody Therapies: Learn about the concept of monoclonal antibody therapies, which utilize humanized monoclonal antibodies to target and eliminate cancerous cells while collaborating with the patient’s immune system. Discover their potential applications in treating hematologic malignancies, solid tumors, and other diseases.

  2. Focus on Daratumumab: Explore daratumumab, an anti-CD38 antibody initially developed for multiple myeloma treatment. Understand how it has demonstrated efficacy in other disorders such as amyloidosis, leukemia, lymphomas, and autoimmune conditions. Gain insights into its mechanism of action and its impact on plasma cells.

  3. Anti-CD47 Therapies: Learn about anti-CD47 therapies, currently in clinical trials, which aim to block the “do not eat me” signal of CD47 glycoproteins. Discover their potential in effectively targeting and destroying cancer cells. Explore the challenges they present in blood banking due to the presence of CD47 on various cell types, including red blood cells and platelets.

  4. Implications in Blood Banking: Understand the impact of monoclonal antibody therapies on blood banking practices. Learn about the potential interference they can cause in serological investigations and blood compatibility testing. Gain insights into the detection and management of daratumumab interference, including the use of dithiothreitol (DTT) treatment.


Join us in this enlightening video as we explore the applications and implications of monoclonal antibody therapies in blood banking. Stay informed about the challenges they present and learn effective management strategies. Enhance your understanding and optimize your blood banking practices for accurate patient evaluation and transfusion management.

For a comprehensive understanding, watch the full video here:
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