This webinar was live on Friday 12 March 2021, and covered the Haemolytic Transfusion Reactions (HTR) chapter of the Annual SHOT Report 2019 with a look at hyperhaemolysis cases and patients with haemoglobinopathies. It includes a 40 minute presentation by the SHOT Team and the SHOT HTR Working Experts Dr Anicee Danaee, Dr Tracey Tomlinson and Dr Joseph Sharif and is followed by short a Q&A session. *Important note – 1) the slide at (5:17) mistakenly says ‘Caution when using O D-negative red cells for transfusion in O D-negative individuals’. It SHOULD read ‘Caution when using O D-positive red cells for transfusion in O D-negative individuals’.